In 1994, Susan Swedo, a researcher at the National Institute of Mental Health (NIMH) in Bethesda, Maryland, had a hunch that there might be an immunological explanation for obsessive-compulsive disorder. As a model, she was studying a phenomenon known as Sydenham’s chorea, or St. Vitus’ dance. First described centuries ago, Sydenham’s chorea is a rare manifestation of rheumatic fever that affects children almost exclusively. It is a disconcerting, unmistakable illness to witness. Children are overcome by rapid, uncontrollable jerking of the hands, feet, and face, contorting their bodies in a distorted, disturbing “dance.” Sydenham’s chorea is caused by molecular mimicry gone wrong. Molecular mimicry generally works like a wolf in sheep’s clothing. Streptococcus bacilli have thrived through the eons by cloaking themselves in proteins that resemble their host’s own cells. Disguised, it evades the immune system just long enough to establish an infection. But sometimes this tactic ...